Press Releases

Bolt Biotherapeutics Expands Board of Directors with Appointment of Kathleen LaPorte

Bolt Biotherapeutics Presents Ongoing Clinical Trial Poster at San Antonio Breast Cancer Symposium 2020 Virtual Meeting Read More

Data Published in Nature Cancer Highlight Preclinical Proof of Concept of Bolt Biotherapeutics’ Boltbody™ ISAC Platform Read More

Bolt Biotherapeutics Presents BDC-1001 Ongoing Clinical Trial Design and Supportive Preclinical Data at Society for Immunotherapy of Cancer Annual Meeting Read More

Bolt Biotherapeutics Closes $93.5 Million Series C Financing Read More

Bolt Biotherapeutics Announces Issuance of U.S. Patent for the Boltbody™ ISAC Technology and its Lead Development Candidate, BDC-1001 Read More

Bolt Biotherapeutics Appoints William P. Quinn as Chief Financial Officer Read More

Bolt Biotherapeutics Appoints Edith Perez, M.D., as Chief Medical Officer Read More

Bolt Biotherapeutics Appoints Nathan Ihle, Ph.D., as Vice President of CMC and Quality Read More

Bolt Biotherapeutics Announces Initiation of BDC-1001 Clinical Trial in Patients with HER2-Expressed Solid Tumors Read More

Media Coverage

Bolt Bio Adds $93.5M to Move Ahead Immune-Stimulating Cancer Drugs

Xconomy

Piramal Pharma Solutions and Bolt Biotherapeutics Sign Production Agreement

ADC Review

U.S. Patent for Bolt Biotherapeutics’ Boltbody™ ISAC Platform Technology is a Major Milestone in the Development of BDC-1001

ADC Review

Randall Schatzman, Ph.D. to Lead Growth of Immune- Stimulating Antibody Conjugates at Bolt Biotherapeutics

ADC Review

How the Next Generation Antibody Drug Conjugates Expands Beyond Cytotoxic Payloads for Cancer Therapy

ADC Review

Bolt Biotherapeutics Nabs $93.5M to Push Provenge Inventor’s New Idea Deeper in the Clinic

Endpoints News

Bolt’s Myeloid Twist on ADCs Charged up with $93.5M series C

BioCentury

Pfizer-Backed Bolt Therapeutics Strikes $93.5M Funding Round As Lead Med Hits the Clinic

Fierce Biotech

Agonist ecstasy? HER2 (and more) ‘Bolt’-on strategy draws $93.5M series C

BioWorld

Bolt Biotherapeutics Initiates Immunotherapy Trial of Lead Drug Candidate in HER2-Expressing Solid Tumors

Precision Oncology News

Podcasts

Dr. Randy Schatzman On Dodging Disruption: The New Fundraising Norm

Business of Biotech Podcast

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CMC Considerations For In-Human Studies with Drs. Edith Perez and Nathan Ihle

Business of Biotech Podcast

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Randy Schatzman, PhD, CEO of Bolt Biotherapeutics

Biotech 2050 Podcast

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Advances in Targeted Cancer Therapy
with Dr. Edith Perez

Empowered Patient Podcast

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Posters & Publications

Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity

Ackerman SE, et al., Nature Cancer (2020)

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Phase 1/2 study of novel HER2-targeting, TLR7/8 immune-stimulating antibody conjugate (ISAC) BDC-1001 as a single agent and in combination with an immune checkpoint inhibitor in patients with advanced HER2-expressing solid tumors

Presented at: 2020 San Antonio Breast Cancer Symposium

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Phase 1/2 study of novel HER2-targeting, TLR7/8 immune-stimulating antibody conjugate (ISAC) BDC-1001 with or without immune checkpoint inhibitor in patients with advanced HER2-expressing solid tumors

Presented at: 2020 Society for Immunotherapy of Cancer (SITC)

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Covalent attachment of a TLR7/8 agonist to tumor-targeting antibodies drives potent anti-tumor efficacy by synergistically activating FcγR- and TLR- signaling and enables safe systemic administration

Presented at: 2020 Society for Immunotherapy of Cancer (SITC)

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Systemically administered HER2-targeted ISACs provoke a rapid, local response that engages the innate and adaptive arms of the immune system to eradicate tumors in preclinical models

Presented at: 2020 Society for Immunotherapy of Cancer (SITC)

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HER2-targeting TLR 7/8 immune-stimulating antibody conjugates elicit robust myeloid activation and anti-tumor immune responses in a TLR- and FcR-dependent manner

Presented at: 2019 Society for Immunotherapy of Cancer (SITC)

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TLR7/8 immune stimulating antibody conjugates elicit robust myeloid activation and durable anti-tumor immunity

Presented at: 2019 American Association for Cancer Research (AACR)

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Systemic Immunity is Required for Effective Cancer Immunotherapy

Spitzer MH, et al. Cell (2017)

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Allogenic IgG Combined with Dendritic Cell Stimuli Induce Antitumor T-cell Immunity

Carmi Y, et al. Nature (2015)

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